>Homo Sapiens_WDR16
MEAVVLPWQIFGVRELPVERGVTMKGPRLFRAPGHVPTGLKCHPDQEHMIYPLGCTVLIQ
AINTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLH
KGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCR
DEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDIL
KMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQ
GGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFAT
CAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMY
VINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVK
RNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWE
VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNI
TRIRISPGNQYIVSVSADGAILRWKYPYTS

>Gorilla gorilla_WDR16
MEAVVLPWQIFGVRELPVERGVTMKAPRLFRAPVVVWSIAKRDAICGSPAAGLNVGNATN
VIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLG
TTTGDILKMNPRTKLLTDAGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKP
IKKIQLQGRITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFG
TAELFATCSKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAP
ETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSS
VSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTD
RKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNECEVTHVG
VGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS

>Pongo abelli_WDR16
MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHVIYPLGCTVLIQAINTKEQNFL
QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWGYKKRELLARLSLHKGKIEALAFS
PNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFVTAGNG
TIRVWELDLPNRKIWPTECQTGQMKRIVMSIGMDDDDSFFYLGTTTGDILKMNPRTKLLT
DAGPVKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPSYKPIKKIQLQGSITSITLRG
EGHQFFVGTEESHIFQVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWH
TSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINSAHRIGV
TAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTAS
TDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL
EGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQ
YIVSVSADGAILRWKYPYTS

>Equus caballus_WDR16
MESQISPKAEVAELELEAVIGFNGHVPSGLKCHPDQEHVVYPLGCTILIQAVNTHEQNFL
HGHDNNVSCLTISKSGIYIASGQVTFMGFKADIILWDYKKRELIARLSLHKGKIEALAFS
PNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATTVIFSRCRDEMFVTAGNG
TIRVWELDLPNRKIWPTECLTGQMKRIVMSLTMADDDSFFYLGTTTGDILKMNPRTKLLA
DTGPAKDKFSLGVSAIKCLKMGGLLVGSGAGLLVFCKSPSYKPIKKIQLQGGITSIALRG
EGHQFFVGTEESHIYRVTFTDFKETLIATCHCEAVQDIVFPFGTAELFATCAKKDIRVWH
TLSNRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPETGRLMYVINNAHRIGV
TAIATTSDCKRIISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKKNNEECVTAS
TDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL
EGSLSGSINGMDITLEGVYFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRVRISPGNQ
YIVSVSADGAILRWKYPSAS

>Loxdonta africana_WDR16
MDTQTSPEAEVAELELEAVIGFNGHVPNGLKCHPDQEHLIYPLGCTVLIQSINTNEQNFL
HGHGNNVSCVAVSKSGVYLASGQVTFMGFKADIILWDYKKRELVARLSLHKGKIEALAFS
PNDLYLVSLGGPDDGSVVVWSIARRDAICGSPAAGLNVGNATTVIFSHCQDEMFVTAGNG
TIRVWELDLPNRKIWPTECQTGQMKRIVMSITMADDDSFFYLGTTTGDIFKMNPRTKLLT
DTGPLKDKFSLGVSAVKCLKMGGLLLGSGAGLLVFCKSPSYKVIKKIQLQGGITSITLRG
EGHQFFVGTEESHIYRINFTDFKETLIATCHCEAVQDIVFPFGTAELFATCAKKDIRVWH
TLSNRELLRITVPNMTCHGIDFMRDGKSIVSAWDDGKRAFAPETGRLMYVINSSHRIGVT
AIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKKNNEECVTAST
DGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELE
GSLSGSINGMDITVEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQY
IVSVSGDGAILRWKYPYAS

>Mus musculus_WDR16
MEEQVLPELDVAELELQAVIGFNGHVPNGLKCHPDQEHLIYPLGCTVLIQAINTNEQNFL
HGHGNNVSCVTISKEGDYIASGQVTFMGFKADIILWDFKKRELIARLSLHKGKIEALAFS
PNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATSVVFSRCRDEMFVTAGNG
TIRVWELDLPNRKIWPTECQTGQMKRIVLSTGMADDDSFFYLGTTTGDILKMNPKTKLLA
DTGPVKDKFSLGVSALRCLKMGGLLVGSGAGLLIFCKSPSYKPIKKVQLQGGITSITLRG
EGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVFPFGTAELFATCAKKDIRVWH
TMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSAHRIGV
TAIATTSDCKRIISGGGEGEVRVWQVGCQTQKLEEALKEHKSSVSCIRVKKNNEECVTAS
TDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIREL
EGSLSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQ
YIVSVSADGAILRWKYPFAS

>Rattus norvegicus_WDR16
MEEQILPETDVAELELQAVIGFNGHVPNGLKCHPDQEHLVYPLGCTVLIQAINTNEQNFL
HGHGNNVSCVTISKEGDYVASGQVTFMGFKADIILWDFKKRELIARLSLHKGKIEALAFS
PNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATSVVFSRCRDEMFVTAGNG
TIRVWELDLPNRKIWPTECQTGQMKRIVMSSGMADDDSFFYLGTTTGDILKINPKTKLLA
DTGPMKDKFSLGVSALRCLKMGGLLVGSGAGLLIFCKSPSYKPIKKLQLQGGITSITLRG
EGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVFPFGTAELFATCAKKDIRVWH
TMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSAHRIGV
TAIATTSDCKRIISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKKNNEECVTAS
TDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIREL
EGSLSGSVNGMDITQEGEHFVTGGHDHLIKVWDYNEGEVTHVGVGHSGNIMGIRISPGNQ
YIVSVSADGAILRWKYPFAS

>Monodelphis domestica_WDR16
MADADTLPEPEVLGLELQAVIGFNGHVPSGLICHPDQEHLVYPLGCTVLIESINTKKQYF
LHGHGNNVSCVTISLNGAYVASGQVTFMGFKADVILWDYAKKELIARLSLHKGKIEALAF
SPNSKYLVSLGGPDDGSVVVWSVTKRDAICGSPAAGFNVGNATTIIYSNCREEMFVTAGN
GTIRVWELDLPNRKIRPTECQTRQLKRVVLSIAMAEDDSFFYIGTTTGDILKLNPRTKLL
ADTGPVKDKFSGGVTTIKCLKMGSVLIGSGAGVVALCKSPSYKPIKKIQLQGGVTSVALR
GQGHQFFVGTEAAHIYCLSYTDFKAELIATCHSGAVQDIVFPFGTADLFATCSKEDIRVW
HTSSNRELLRITVPNMTCCAIDFMRDGKSIISAWNDGKIRAFTPETGRLMYVINNAHSIG
VTAIATTSDCRRIISGGGEGQVRVWEISPQSQKLEEALKEHKSSVSCIKVKKNNEECVTA
STDGTCIIWDLVRLKRNQMILANTLFQCVCYHPEEFQIITSGTDRKIGYWEVFDGTVIRE
LEGSLSGSINGMDISSEGVHFVTGGDDHLVKVWNYSDGEVTHVGVGHSGNIIRMKISPNN
EHIVSVSADGAILRWKCPFTS

>Gallus gallus_WDR16
MATATPEERAAGGLELQAAIGFNGHVASGLICHPDNKHLLYPLGCTVVIQDLASKKQTFL
HGHTNNVSCVVVSRSGNYVASGQVTFMGFKADIILWDFQKKELLARLSLHKGKIEGLAFS
PNDLYLVSLGGRDDGSVVVWNVSKREAVCGSPASARSAGNVTIVECSACRDEMFVTAGSE
TIRVWELDLPNRKLRPTECQTGQLRRVITSLQIADDDNYFYVGTSTGDVLKVNTRNKLMT
DFGPQKKFSLGVTALLLLKTGDVIIGTGEGTVALCKGSNYRVMKNIQVHGGVTSLTRRGQ
GHQFFVGTKMCQIYRVNYTAFKEELITTCHSEAVHDIVFPFGTSDLFATCSKDDIRVWHT
PEHRELLRIVIPNMTCYAIEFMRDGKSIISAWNDGKIRAFMPESGREMYVINNAHSRGVT
AIAATSDCKRIVSGGGEGQVRVWAIGEKTRKLEGVLKEHISAVSCIKIKKNDKECVTASL
DGTCIIWDIGRFTRKQMILANTLFKCVCYHPEEYQLITSGTDRRIGYWEVYDGSAIRDLE
GSLSGSINGMDITSDGAYFVTGGDDHLVKMWDYNEGTVTHIGVGHSGNITRLKICPGNKY
IVSVSADGAILLWKYPGCP

>Anolis carolinensis_WDR16
PNEEAAPPEDLAGLQLEAIIGFNGHVPCGLICHPDREHLIYPLGCTVIVQGINIRTQEFL
HGHTNNVSCVTISASGSYVASGQITFMGFKADIILWDYNKKEMWARLSLHKGKIENLAFS
PNDLYLVSLGGQDDGSIVVWSIQKKEAICGSPASARSAPNPTSLVYSNCRDEMFISAGSG
TIRVWELDLPNRKIRPTECHTGQLKRIVTCIMITDDDKYFCIGTSTGDIVKLNTKSTLMS
DYGPVKDKFSLGVTALLLLKTGDLVIGTGTGLIALCSASNYKVKKKVQLQGAITSITPRG
QGHQFFVGTEEAHIYRFSYSDFKDELIATCHNEAIHDIIFPYGTSDLFATCSKSDIRVWY
TPENRELLRITIPNMTCHAIDFMRDGKSIISAWNDGKIRAFTPETGRLMYVIEHAHSMGV
TAVASTSDCKRIISGGGEGQVRVWEIGKETRTLEEVMKEHISSISCIKIKKNNQECVTAS
IDGTCIIWDLVRFMRRQMILANTLFKCVCYHPDEHQLITSGTDRKIAYWEVFDGSPIRDL
EGSLSGSINGMDITSDGAYFVTGGDDHLVKVWDYNEGEVTFVGVGHSGNITRLKICPNNK
YIVSVSADGAILRWKYPHVH

>Pelodiscus sinensis_WDR16
MGFKADIILWDYKKRELLARLSLHKGKVEKLAFSPNDLYLVSLGGQDDGSVVVWSIAKRE
AICGSPASARSAGNATVLAFSSCRDESFVSAGNGTIRVWELDLPNRKIRPTECQTGQLKR
VVTCIMMAEDDSYFYVGTSSGDLLKLNMKSKLMSDYGPVKEKFSLGVTALLLLKTGELVV
STGGGVVALCKGSNYKPIKKIQVQGGITSLTGRGQGHQFFVGTEESQIYRLNYNEFKEEL
IATCHNEAIHDIIFPSETSDLFATCSKSDIRVWHTPENKELLRITIPNMTCHAIDFMRDG
RSIISAWNDGKIRAFTPETGRLLYVIDHAHSMGVTAIATTSDCKRIISGGGEGQVRVWEI
GQHTRKLEGVLKEHISTISCIKIKKNNRECVTASTDGTCIVWDLVRFMRNQMILANTLFQ
SVCYHPEEHQIITSGTDRKIGYWEVFDGSAIRNLEGSLTGSINGMDITSDGTYFVTGGDD
HLVKVWDYNEGEVTHVGTGHSGSITRIKICPGNKYIVSVSADGAILRWKYPHSP

>Xenopus tropicalis_WDR16
KRRTVMAEQGEDNRLELQGIIGFNGHVPSGLISHPDREHLIYPLGCTVIIENLSSRKQQF
LQGHTNNVSCVAASRSGRYLASGQVTYMGFKADILLWDYGRREACAKLTLHKVKVEALAF
SPNDLYLVSLGGQDDGSVVVWNVAKREAICGSPASSLSSGHATTIIFTNNSDDIFMTGGN
GTLRVWDVDLPNRKMRPTECQLGQMKRVVTCLQVAEDDSCFYCGTSSGDILTINTKSKLL
SSFAPQKGKFSLGVTALRLLKTGELLVGSGDGKLALCKGPNYKAAKTVQLQGSVTSISLR
GQGHQFFVGTGGAQIYRFSYPEFKEELIATCHSEAINDIAFPFGTSELFATCSKNDIRVW
HTATHKELLRITVPNMTCLAIDFMRDGKSIISAWNDGRIRAFMPESGRLMYCIENAHSMG
VTAIAATSDCKRIVSGGGEGQVRIWEISKETQRLVQSMKEHKSSVTCIKLKGNNRECLTA
SSDGTCIIWDIVRFTRLQMVLSNTLFRCVCYHPEEFQFVTSGTDRKVGYWEVFDGSAIRE
LEGSKSGAINGMDICDQGAHFVTGGDDKLVKVWDYNEGEVTHVGIGHSGNITRLKICPLS
KYIISVSTDGAILCWDYPYGLR

>Latimeria chalumnae_WDR16
FPFPLLTGQVPAGLIAHPDRENILYPLGCTVIIQSLKNKKQSFLHGHTNNVCCLGVSRDG
TYLASGQVTYMGFKADVIIWNYAQRELYARLSLHKAKVQSVAFSPNGLYLATLGGQDDGS
LVIWNVAKKEAICGSPASAVSSGNALTVKFSNHSDEIFITAGNTTIRVWELDLPNRKIRS
SECQTGQLKRIVNCIEISEDDAFFYCGTTTGDILKLGLKNKLLSSYAPQKEKFGLGVTAL
ALLKTGDFLVGSGDGFVALCKPSTLKIVKKAHLHGAVNSIALRGEGHQFFAGTGCAQIYR
FNYVEFKEELIAACHNEAVNDIAFPFGTSELFATCSKSDIRVWHTQSKKELLRITIPNMT
CHGIDFMKDGKSIISGWNDGKIRAFTPESGRLMYVINNAHSIGVTAIAAIGSCKRIVSGG
GEGMVRVWEIGQGFNTLIESMKEHKASVSCIRVKSNDQECVTASTDGTCIIWDIVRFVRN
QMVLANTLFRCVCYHPEGYQIITSGTDRKIAYWEVFDGTPIRELEASVSGSVNGMDISQD
GKYFATEPGGDEKLIKLWGYNEGEVTHVGIVHNDFIITVDPEDDDGGFKNNPPCGLGANS
DKLAEEVPASGGETVTGKKSTTLTSQGSAKERLSSWCYYGDKTPGVQGLKNHGNTCFLNA
VVQCLSNTDLFAEYLGLEQYKSDLNQGKLNGIVRSNSGELQGRGEVTEQLASLVRALWTL
EYTPQLSVEFKVSGPKKNLI

>Takifugu rubripes_WDR16
MDADTHGLPPVELRAVFGFNGSVRSGLSVHPDGEHLIYPLGSTVVLRTIKDGRQELLQGH
TSDVSCVSVSRSGSLIASGQVDCMGFKAVIIIWDYPQRRSSAQLLLHEAKVEALDFSPDE
KYLVSLGGQDDGRVVVWNVETRQAVCGSAASGRSTSPCLTVRYSNTNSNLFVTAGSSALR
VWELDPLNRKIQPTECQTGILKRAVECIEISEDDEFVFCGTTSGDIMKFNLKTRRLSDYG
PKRFSAKHSRSVSALRTLKGGHLLVGSGCGKLMLCSASSFQALKEAQLEKAVTSIALSGE
GQQFFVGTEAAQMYGFRSEDFRAELISSSHRSAVKDVAICFGTSELFATCSEEDIRVWHI
DKPKELLRITVPNMTCNALDFMSDGHSIISAWNDGKVRVFAPESGRLVLIIHDAHNTGVT
AIAGTRNCKRIISGGGKGMVRVWELQPKGHRLLETMKEHRGAVTCIKIKSDDKECVSASS
DGACIIWDLVRFVSLKMVITTRLFRAVCYHPDIYQIITSGTDRKVVYWDAYDGSAIRELE
GLLTGSINAMDISQSGTHFVTATSGGDDKLVKVWDYMEGAVTHVGMAHGGSITGIKLCSN
SSTLISTSADGAVVLWRFPHSPA

>Tetraodon nigroviridis_WDR16
MQADAHGVASVELRSVFGFNDPGRVCSGLRLHPDRERLLYPLGSALILRTIKDGQQELLQ
GHTNDVSCLSVSRSGSYVASGQVDCVGFKAAIIIWDYAQRGIYAQLLLHEAKVEAVDFSP
DEKYLVSLGGQDDGRVVVWNVASRQAICGSPASGRSSSSCLTVQFCNTNSNLFVTAGSSA
LRVWELDPQNKKMEPTECRTGILKRVVTCIEISEDDQFLFCGTTSGDILKINLRTRLLSD
YGPKRSSAKHGRSVSALRMLRSGHLLVGSGCGKLMLCSATGFQALKEAQLEKAVTSIALS
GEDQRFFVGTEAAQMYSISCQDFRPELVSSSHRSGVKDVAICFGTSELFATCSEEDIRLW
HIDKPKELLRITVPNMTCNALDFMTDGHSIISAWDDGKIRVFAPESGRLMLIIHGAHNMG
VTAIAGTRNCKRIISGGGTGMVRVWELQSKGHRLLETMKEHKGTVTCVKIKGDDKECVSA
SSDGVCIIWDIVRFVSLKMVITNRLFRAVCYHPDIYQIITSGTDRKVVYWDAYDGSAIRE
LEGLLAGSITAMDISPSGSHFVTGGDDNLVRVWDYMEGVVTHVGTAHGGSITSIKLCSNS
STLISTSADGAIVLWRFPHSPT

>Gasterosteus aculeatus_WDR16
LDETMSLETHGVPQLELEAVIGFNGYVSSGLRVDPDSEHLIYPLGCSVILKRIKGGKQES
LHGHSNNVSCVSVSKSGSYIASGEVTFLGFKAVIIIWDYAQRSIYAKLQLHKAKIEALAF
SPNDKYLVSLGGQDDGRIVVWNIETKQAICGSAASPGMAGDCLTVQYSNTDDNVFVSAGS
GTLRVWELDRANCRIQPTECQTGRLKRIVKCVQISEDDQFIFCGTTSGDIMEINLKMGRL
TNCGPTEGKYSMGVNVLRILQCGDLLVGSGSGILTLCSGTNFKTLNFSQNKKVPLEKGVT
SLAIGGEGKQFLVGTEAAQMYRFGCDFRKELISTSHNSAVKDGLICFGTSELFATCSDDI
RLWHRDNERLRIIVPNMTCNSLDIMLDGHSIISGWNDGKIRVFAPESGRLMLIIHDAHQR
GVTAIAGTRDCKRIVSGGGDGQVRIWELLPHGHRLVETMKAHTATINCIKIKSDSKQCVT
ASADGACIIWDLVRFLSLQMVMTNTRLRDVCYHPEEYQIITSGSDRKVAYWDVFDGTLIR
ELEGSKFGSINGMHISQDGKHFVTGGDDKLVKVWDYMAGTVTHVGIAHGASITRVKICSN
NRTIISTSADGAILRWRFPHPSPS

>Oryzias latipes_WDR16
SAESQFPKINIPQLELEAVIGFNGRVPSGLRLHPDKQHLIYPLGCTVILRSISDDKQEFL
HGHTNNVCCLSVSRSGTYIASGQINFLGFKTTVFIWDYAQRSVYAELVLHKAKVESLAFS
PNDKYLVSLGGQDDDSIVVWNIETKQAICGSTATSHVARHCLVVQYSNTDDNVFVSAGRG
SGTLRVWELDVANRKIRPTECKLGKLQRNIKCVEISNDDQFLFCGTTSGDILKVNLRTGL
LSDFGPVKAKHSLGVSVLRVMESGDLLVGSGSGVLTLCSKTNFKMLQSIQLEKGVTSITI
KDTGQQFFVGTEAGLIYRMSSDDFKAEVVFTSHTSAVKDVVMPFGTSELFATCSDDDIRL
WHIDKPKELLRIPVPNMTCNALDFMIDGHSLISAWNDCKIRAFGPETGRLMFTINDAHKM
GVTAIAGTRDCKRIVSGGGDGQVRVWELLPHCHRLVEIMKEHKATVSSLKIKSNDKECVT
ASVDGTCIVWDLERFVGLQRMIANTVFRAMCYHPEEHQIITSGTDRKLSYSFLYDGSIIR
ELEGSQSGAINAMHITKDGGYFVTGGDDRVVRVWSYMEGVVTHVGIAQGGSITSMKICSN
NRILVTTSADGAIMQWKFPHPP