>Homo sapiens RNF223
MSSGQQVWHTAVPPPRRSSSIASMPRSPSSAGSPRSPGTPGSERVASPLECSICFSGYDN
IFKTPKELSCTHVFCLECLARLAAAQPVGRPGGEAVPCPFCRQPTAVPPAGAPALCTSRQ
LQARMPAHLRREEPVWLEGTKLCCQPLPTTPGREPGFVCVDVGLSKPAEPPAPARDPAPR
RGRLARCWARCRDWRRMALVSALLLMLFCVALWPVQCALKTGNLRCLPLPPRPPATSTAA
SPLGPLTDN

>Gorilla gorilla RNF223
MSSGQQVWHTAVPPPRRSSSTASMPRSPSSAGSPRSPGTPGSERVASPLECSICFSGYDN
IFKTPKELSCTHVFCLECLARLAAAQPVGRPSGEAVPCPFCRQPTAVAPTPGREPGFVCV
DVGLSKPAEPPAPARDPAPRRGRLARCWARCRDWRRMALVSALLLVLFCVALWPVQCALK
TGNLRCLPLPPRPPATTAAASPLGPLTDN

>Macaca mulatta RNF223
LSHSSETCRPASRCGTRPCPPIAGAAPQPRCPGPPARLAAPGPTPGSEKVASPLECSICF
SGYDNIFKTPKELSCTHVFCLECLARLAAAQPVGRPGGEAVPCPFCRQPTTVPPAGAPAL
RTSRQLQARMPAHLRREEPVWLEGTKLCCQPLPTTPGHKPSFVCVDVGLSKPAEPPAPAQ
DPAPRRGRLARCWMRCRDWRRMALVSALLLVLFCVALWPVQCAIKTGNLRCLPRQPPSPS
STGGSPTGGLKGAAATG

>Canis familiaris RNF223
YQSGVQAVQTALPDSRCGTAMSAPSRTSPTAPAPRSPSTPGSEKVASPLECSICFSGYDN
IFKTPKELSCTHVFCLECLARLAAAQPTGRPGGEAVPCPFCRQPTAVPAAGAPALRTSHQ
LQARMPAHLRREEPVWLEGTKLCCCLPPSVPGLGEPGIVCVDVGLSKPAEPTAPTPAPGP
ARRQGRLARCWARCRDWRRVALVTALLLVLFCVVLWPVQCALKTGNLHCLPRPSTTITTA
TAFSSRPLADN

>Felis catus RNF223
APGRTSPAATVPGSPSSASSPRSPSTPSSEKAASPLECSICFSGYDNLFKTPKELSCTHV
FCLECLARLAAAQPTGQPGSEAVPCPFCR

>Bos taurus RNF223
MSSGPQVWHTTMPLTSRSSPTATVPRSPSSASSPRSPGTPGSEKVASPLECSICFSGYDN
IFKTPKELSCTHVFCLECLARLAAAQPTGQPGSEAVPCPFCRQPTAVPAAGAPALRTSRQ
LQARMPAHLQQEEPVWLEGTKLCYYPSPSVPGPVEPGFMCVDIGPSKPPEPAVPVPTPDP
AHRRGPLARCWARCRDWRRVALITALLLVLFCVVLWPVQCALKTGSLRCLPRPPSTAATT
SSLGSLAYN

>Equus caballus RNF223
LSHSSEPCHQASRCGTQPRHATAGAVPQPQCPGPPAQPAVPGPPSTPGSEKVASPLECSI
CFSGYDNIFKTPKELCTHVFCLECLARLAAAQPMGQPGGEAVPCPFCRQPTAVPAAGAPL
RTSRQLQARMPAHLQHEEPVWLEGTRLCCCPPPAAPGLTAPGFMCVDVGLRKPAEPAAPP
PTLGPTRPQGRLAHCWARCRAWRRVALVTALLLLLFCVVLWPVQCALKTGNLRCLPRAPT
TAATAAAFSLGPLADN

>Loxodonta africana RNF223
LCLSHSSEPCHQTSRYGTQPCHPTAGAAPQPQCPGAPTQPTPGTPVSEKVASPLECSICF
SGYDNIFKTPKELSCTHVFCLECLARLTAAQPIGRPGSEGVPCPFCRQPTAVPPDGAPAL
RTSRQLLAKMPAHLRREEHVWLEGTKLCCRPPPSSPGHNSPTFICVDVGLSKPAEPAPPL
FPPGPLRRQGRLARCWARCRDWRRTALVSVLLVVLFCVVLWPVQCALRTGNLQCFPRPSG
AATTATSKMLPLGPLADN

>Myotis lucifugus RNF223
QQCAGSKTAGPPCQWSRMASEATNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFC
ERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNVEESSI
LETVTAVAAGKPLSCPNHDGNVMDFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKA
SLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLL
MELEVNYGLKHKVLQSQLDTLLEGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNE
LADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQP
MSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTL
SLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKKRVKSPGSGHVKQKAVKRPASMYSTGKR
KENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRF
GIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSV
DRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIVTDFHN
HSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFL
SYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ

>Gallus gallus RNF223
MSCFTQLWHSSTPDPIVITSPVDSKRKARSPTDKPGSPNPTSPKPASPVECSICFNTYDN
TFKTPKLLQCSHVFCLECVARLSKGLPPNHPEDQLPCPFCRQLTSIPQEGAPALETSKEL
LATLPPELQQEKVLWMEGTKLCCRQASDDPENPDSCISIDVAMSKPESPEVPPTGLVGRL
SRCDMCDDWKRIVLLSALIIILFCIILWPVQCALKTGNLRCFTRPHGPQRPFCAHTWMGA
LTSS

>Pelodiscus sinensis RNF223
MSWLPQMRRTETPRSPSSPIPAAQDEVPIPISPIIVTSPTYGRKLSSPTSPKPTSPIECS
ICFNTYDNSFKTPKLLQCTHVFCLECVARLTSALPPHRVEDHLPCPLCRQPTEIPLEGPP
ALQTSKELLSTLPPELQREKLVWMEGSKLCCRQSSQDTEDPNACIWLDVAMSKPNVPTTP
TEGMAGRLSRCAICDDWKRIVLLSALAIILLCIILWPVQCALKTGNLRCFTRTVTYTRPG
TTLFTQNNSTVPGTSLLSN

>Xenopus tropicalis RNF223
SRLECSICFTKYDNIFKTPKLLQCSHTLCLECVARLVAALPPEKQAEDVLCPFCRQPTHI
PDDGAPALQTSQELLSTLPAHLQHEEPVWIEGNKLCYKKPPETNPDQHDLCICVDIGLSK
KDSPTEPRQRRGCFRGCSDWKRLLLIAFIVAVLFCILLWPVECILKTGSLRCTSEPVPTR
IPVVPAVVTHGPIDER

>Takifugu rubripes RNF223 b
METLEEDLTCSVCYSLFSDPRVLPCSHTFCKTCLDNLLQVSNNYSIWRPLRLPLKCPNCR
SMVELPPTGVEALPSNVSLRAIIEKYQSDNEPRPPSCQEHHRQPLNMYCIQDRQLICGLC
LTVGQHQGHPIDDLQAAFTREKRTPSLLLAKLSESRWAQVVCELGEQLEQEKARCEDLLR
QDRHNVSQYFHSLEVVLAKKRRACLDALDKAAGEVCRAYDPLIHKVKELQEEQLDLVSFG
SLVEEEESPLVFLEKVHLFRERVEEFTACPLPSVVNMSLTPRAADFLQQHWASVSIQGLE
DAPVPKLAVSFQRRACTWISLQREGVQTVHQLQLCITTQGEHLVVLLQFVGDHVEARHEL
IETL

>Gasterosteus aculeatus RNF223 a
MFPAPRSAAAALFHLTTPPDVPPPQQVPDSLPPPTHPSISNMSEDREGRAAAPPPNVKPK
LGQTERRSKEGTWKKEKPPKERRSRSTHSEREDERRGRERDRHRGGRSRRGRSEEARGRD
GRGSASGRVKPPEDEVEDTECAVCFCSYDNIFRTPKLLACGHTFCLECLARINVTSARLK
TLSCPVCREPTELPHGRDLPRLGTNKDVLGRLPPDMRRVLSIRFKRSKGKLQLKNPPPAG
RDKNSVRQPSKIQGGAVPAGGHSDLSALE

>Gasterosteus aculeatus RNF223 b
IELQSPEVDAPSADELECKICYSAYNLAARRPKVLGCCHRLCAKCLAKILDLGESPPDAV
ACPFCRYVTGLPGQAVSGLPDDCNLAAALALQSRNQRNLHSRQEATTELLLSPGLLSSLM
GGGPPTTGSPNFVVITIMETPPPPMPLPASGEDLRRQPRGPRGGFRSSSLDSTASIAHRW
TAWNCASQLCQTSARVLVWVLGLLYFSSLPMGVYLLIMQRTTVGLLLVSLVPASLVVIMV
YGFCQCVYHELWDCVPP

>Oryzias latipes RNF223 b
MDSLEEDLTCSVCYQLFSDPRVLPCSHTFCQPCLENLLQVSTNYSIWRPLRLPIKCPNCR
SVVELPPAGVDALPSNVSLRAIIEKYQRDEEPRPPSCQEHPRQPLNMYCIQDRQLICGLC
LTVGQHHGHPIDDLQAAFAREKATPQQLAELSEHRWAEVCELGEQLEQEKTRCEGLLRQD
RDDVTQFFHSLALVMAKKKEAYLEVLDKAAAEVSQAYDPLIQRVKELQEEQLELMSLGSS
VEEEEESPLAFLEKVHLFRERVDKFLKAPLPHAIKLSVTPRAADYLQQHWPPLTIGALEE
APVPAVCCCTRRGSASWKRSPVYSVAWGPDSDRILYTSGVQLTIKPLQPSAKVMQWKAHD
GLVLKVDWNSVNSLILSGGEDCKYKVWDSFGRLLHSSSPHDYPVTSLSWAPDGEMFAVGS
FNTLRLCDKTGWSYAVEKPHTGSLFSLAWSADSTQLAGACGNGHVIFAHVLEQCWEWKNF
VITLTKRRSMQVTNVMNDAVDILDFRDPVIKASLAFAHLVVATSLQCYVYSSRNWNTPLI
FDLKEGTVSLILQAEKHFLLVDGAGLYVFSYEGRLISSPKFLDMRADSLNAQVISLCDDT
IAIRDNRDEKVILFFDVLTGKAVGDGNPLTHKLEVVEIALDQCGPATDRKIALIDKNRDL
YLASVRHFGRETKICKIGTMVDNIAWNDAANILCGIQDNQLTVWCYPSVVFTDKELLPKT
LHIRDSSEFNSAPRILNFSGTKVTLRQGDGSLVYSSVPPYIALLHEYCSSARWEDALCLC
RLVKDQSLWACLASMAMANRELTTAEMAYGAIGELPRVEYISMIKEQPSKESALAHMLLF
SGQVQEAESALLQAGLIYQAIQVNIDLFNWERALELAVKHKTHVDTVLAHREKFLQKFGK
KETNKRFLHYSEGVDVNWENIRAKIEMELSKEREKAANASVRSNGASY