>Human_WIPF1 ----MPVPPPPA--------------------PPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKT-VTNDRS APILDKPKGAG--AGGGGG----GFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQ--AGMPKLRSTANRDN-DSGGS-- RPPLLPPGGR---STSAKPFSPPSG--------------PGRFPVPSPGHRSGPPEPQRNRMPPP-RPDVGSKPDSIPPP VPSTPRPIQSSPHNRG---SPPVP-GGPRQPSPGPTPPPFPGNRGT---------------------------------- -------------------------------------ALGGGSIRQSPLSS--SSPFSNRPPLPPTP--SR--------- -ALDDKPP--PPPPPVGNRPSIHREAVPPPPP-QNNKPPVPSTPRPSASSQAPPPPPPPSRPG-----PPPLPPSSSG-- -N-DETPRLPQRNLSLSSSTPP-LPS-------------------------------PGRSGPLPPPPSE--------RP PPPVRD-PPGRSGPLPPPPP-VSRNGSTSRALPATPQLPSRSGV----DSPRSGP--RPPLPPDRPSA------------ -GAPPPPPP---------------------------------------------------------STSIRNGFQDSPCE ---DEWESRFYFHPISDLPPPEPYVQTTKS----------YPSKLARNESR--SGSNRRERGAPPLPPIPR--------- --------- >Mouse_WIPF1 ----MPVPPPPA--------------------PPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKT-VTNDRS APILDKPKGAGASAGGYGG----GGGGGGG-GGGGGGGSGGNFGGGGPPGLGGLFQ--AGMPKLRSTANRDN-DSGGS-- RPPILPPGGR---ATSAKPFSPPSG--------------PGRFPAPSPGHRSGPPEPPRNRMPPP-RPDVGSKPDSLPPP VPNTPRPVPSSLHNRG---SPAGL-GAPR--------PPFPGNRGA---------------------------------- -------------------------------------AFGAGSARQNPSGS--SSPFP-RPPLPPTP--SR--------- -ALDDKPP--PPPPPVGNRPSMHREAVPPPPS-QTSKPPVPSTPRPGLGSQAPPPPPPPSRPG-----PPPLPPAS---- -N-DEIPRLPQRNLSLTSSAPP-LPS-------------------------------PGRSGPLPPPPSE--------RP PPPVRD-PPGRSGPLPPPPP-INRNGSTARALPATPQLPSRSGM----DSPRSGP--RPPLPPDRPGA------------ -GAPPPPPP---------------------------------------------------------STSVRNGFQDSSCE ---DEWESRFYFHPISDLPPPEPYVPTTKT----------YPSKLARNESR--SGSNRRERGAPPLPPIPR--------- --------- >Rat_WIPF1 ----MPVPPPPA--------------------PPPPPTFALANTEKPSLNKTEQAGRNALLSDISKGKKLKKT-VTNDRS APILDKPKGAG---GGYGG----GSGGGGG-GGSSGGG--GNFGGGGPPGLGGLFQ--AGMPKLRSTANRDN-DSGGS-- RPPILPPGGR---ATSAKPFSPPSG--------------PGRFPAPSPGHRSGPPEPPRNRMPPP-RPDVGSKPDSLPPP VPNTPRPIPSSLHNRG---SPAGL-GAPR--------PPFPGNRGA---------------------------------- -------------------------------------AFGAGSVRQNLSSS--SSPFP-RPPLPPTP--SR--------- -ALDDKPP--PPPPPVGNRPSMHREAVPPPPS-QNSKPPVPSTPRPGAGSQAPPPPPP-SRPG-----PPPLPPTS---- -S-DEIPRLPQRNLSLTSPTPP-LPS-------------------------------PGRSGPLPPPPTE--------RP PPPVRD-PPGRSGPLPPPPP-INRNGSTARALPATPQLPSRSGM----DSPRSGP--RPPLPPDRPGA------------ -GAPPPPPP---------------------------------------------------------STSVRNGFQDSSCE ---DEWESRFYFHPISDLPPPEPYVPTTKT----------YPSKVARSESR--SGSNRRERGAPPLPPIPR--------- --------- >Opossum_WIPF1 ----MPVPPPPA--------------------PPPPPTFALANTEKPSLNKSEQAGRNALLSDINKGKKLKKT-VTNDRS APILDKPKGSGGGGSGFGG----GSG-TGGFGGSCGGASGGGFGGSGPPGLGGLFQ--AGMPKLRSTANRDT-DSGGI-- RPPILPPGGR---ATSAKPFTPPGG--------------VGRFPTPSPGHRSGPPEPLRNRMPPPPRPDLSSKPDSGPPP VPSTPRPTQSNLHNRG---SPPVPSGIHRQPSLGPTPPPFPGNRSA---------------------------------- -------------------------------------GFG-GSVRQSSPGS--SSPFSNRPPLPPAP--SR--------- -AMDDKPP--PPPPPMGNRPAINREGAPPPPPPQNNKPPVPSTPRPSSSSQAPPPPPP-SRPG-----PPPVPPVSIG-- -N-DETPRLPQRNLSLTSSAPL-LPS-------------------------------PGRSGPLPPPPNE--------RP PPPVRD-PPSRSGPLPPPPP-INRNGNTSRALPSTPQLPSRGGL----ENQRGGP--RPPLPPDRPGS------------ -GALPPPPP---------------------------------------------------------SSSMRNGFQDLSCE ---DEWESRFYFHPLSDLPPPEPYVPMTKS----------YPSKVARNESR--SGSNRRERGAPPLPPIPK--------- --------- >Platypus_WIPF1 ----MPVPPPPA--------------------PPPPPTFALANTEKPSLNKSEQAGRNALLSDISKGKKLKKA-VTNDRS APILDKPKGGGGGGGGFGG----GSSGGGGSGGGFGGG-------GGPPGLGGLFQ--SGMPKLRSTANRDN-DSGGS-- RPPILPPGGR---AMSAKPFSPPSG--------------PPRFPGSSPGHKGGAPELQRSRMPPPPRPDASCKPDGGPPP IPNTPRPFQSSFHNRG---SPPVP-GVPRQPNLGPTPPPFPGHRNP---------------------------------- -------------------------------------ASG-GSIRQSSPGP--PSPFFNRPPLPPAP--GR--------- -AMEDKLP--PPPPPLGNRPMINREGAPPPPP-QNNKPPVPSTPRPTTTSQAPPPPPPPSRPG-----PPAFPPGSGG-- -G-DEIPRLPQRNLSLTSSGPL-LPS-------------------------------AGRSGPLPPPPME--------RP PPPVRE-PPSRSGPLPPPPP-INRNGNIARASPA-PQLPSRGGL----ETQRGGP--RPPLPPDRPGS------------ -GAPPPPPPP--------------------------------------------------------SSSIRNGFQDSPCE ---DEWESRFYFHPVSDLPPPEPYVPMNKN----------YPSKLARSESR--SGSSRRERGAPPLPPIPR--------- --------- >Chicken_WIPF1 ----MPVPPPPA--------------------PPPPPTLALANTEKPTLSRSEQAGRNALLSDITKGKKLKKT-VTNDRS APILDKPKGSSGGGGGFGG---------GGGGSSGGG-----FSGGGPPGLGGLFQ--AGMPKLRSAASRDA-DTGAA-- RPPALPPGAR---SAAAKPFSAPSG--------------PPRFPGPPLGQRSPAADPQRSRLPPP-RPDVGSKPEATPPP VPSTPRPIASSLHGRG---SAPAP-VLNRQPSLGPTPPPFPGSRAA---------------------------------- -------------------------------------GSA-GSLRQPGPGP--ATPYSGRPPLPPTP--GRS-------- -PVDEKPP--PPPPPSGHRPTASRDMALPPPPPQNSKPPVPASPRPPLGVPAPPPPPS--RPG-----PPPVPPGPAS-- -S-DEMPRLPQRNLSLVPPAAP-SSG-------------------------------SGRSGPLPPPPSE--------RP PPPIRD-PPSRAGPLPPPPP-ISRNGSTSRALPAAPQLPSRAGL----ENQRGGP--RPPLPPDRPGT------------ -GAPPPPPPP--------------------------------------------------------SAALRNGFQES-GD ---DEWESRFSFHPISDLPPPEPYVPVNRS----------YPSKLARNENR--GGSARKERGVPPLPPIPR--------- --------- >Anolelizard_WIPF1 ----MPVPPPPA--------------------PPPPPTLSVANTEKPSLNKSEQAGRSALLSDITKGKRLKKA-VTNDRS APVIDKPKGLGGGGGGGGGFTSSGGGGGGGGGSSGSSSSSNSYSGGGPPGLGGLFQ--AGMPKLRST-NRDN-DSVGS-- RASVFPPGGW---ATSAKPFSAPGV--------------IGRFPGPSPSQRTPAMEPQRSRMPPP-RPDAGSRPDTGAPP VPNTPWPIPSSLHNRG---APLLP-GTSRQASLGLTPPPFPGNR------------------------------------ --------------------------------------FG-GSMRQTSPGSPSSSPSSNRPPLPPAP--AR--------- -PIDEKPP--PPPPPAGNRPPLSREPSLPPPPPQNNKPPVPSTLRPSFGSPVRPPPLP-NRPG-----PPPVPPMFGG-- -N-DEMPRLPQRNISLASPAPPTLTS-------------------------------SGRSGPLPPPPNE--------RP PPPVRD-PPSRSGSFPPPPPPINRNGCTLRALPATPQLPSRGGF----EKHRGGS--VPPLPPDRPGS------------ -GAPPPPPPPP-------------------------------------------------------SSAMRNGFQDSSCE ---DEWESRFSFHPLSDLPPPEPYVPINKS----------YPSKLGRNDNR--SGSSRRERGAPPLPPIPR--------- --------- >Zebrafish_WIPF1 ----MPIPPPPP--------------------PPPPPTFSQANTEKPVLNRSEQQGRNALLSDISKGARLKKA-VTNDRS APVLDKPKGGGG-----PGGGGGGGGGGGGFGGGGGGG------GGGGGGLGGLFQ--GGMPKLRSTR----DDSVSV-- RPPVLPPVAR---TTGPRPFGGGSGS-------------APRLP----VQRSESFDPPRARMT-PPRPET---PGGPPPP LPSAPRPFQSSTQSRG---PPALPGTPRFGSAPTPPPPTLP-GRQPAPPPV----------------------------- -----------------------------------PGGIG---RP--PSVPSPSTGHAGRPPPPPAP--GRG-------- ----EDRP--PPVPPANRSMPLTRD-SPPPPP-----PPSASSKPTPPPAPSPACLRPPVSAA-----PPLPPGRPSPNT PD-EHTPRLPERNLSLASHPPA--PP-------------------------------PGRSGPLPPPPSE--------RP PALGRN-ASGRSGPLPPPPPSGR-PGGGSMRSSPAPPPPNRPGV----ETHRGG--SRPPLPPDRPSS------------ -G-PLPPPP----------------------------------------------------------APIGNGYHSQHHI ---DEWESRFTFRPVSDLPPPDPYIPCQKT----------YPSKIVRNESR---GSGKKERGAPPLPPIPR--------- --------- >Fugu_WIPF1 -------------------------------------------------------------------------------- ------------------------------------------------------------MPKLRSAASRESNDSAPS-- RAPVLPPGGR---SCAPTPFGGGG---------------PPKLPGAPPSSRGSVPDLPRGRP--NVRQDT---PGGAPPP IPSTPRPHH-GIQSQGSPSPPSLPG--RPSPS--PAPPSVPPGRHGPLPPL----------------------------- -----------------------------------PGGHSPGSRAGFAAAPPPPVPNGGRPPLPPTP-GGKS-------- -QFSDDRPPLPPVPAGGYRPTANRD-TPPLPPSFNSKPVSSSSSPASRPLLGGPPPIPPGRPG-----PPPIPPIPSG-A DD-HSVPRLPQRNSSLNSHGPS--TP-------------------------------HGRSGPLPPPPNE--------RP PALGRNQSSVRSGPLPPPPSSARSIGGGSMRSSAAPSPIVRPGL----DPPRGGPGGRPPLPPDRPGI------------ -GGPLPPPP----------------------------------------------------------P-MGNGFQNSHHN QIQDEWECRFNFHPASDFPPPEPYIPCQKT----------YPSKLTKTDGRVLSGSGKKERGAP--PPVPR--------- --------- >Stickleback_WIPF1 -----PPPPPPP--------------------PGPPPTFSIANTEKPSLNRSEQSGRNALLSDIAKGSRLKKA-VTCDRS GPLLDSKSTSAWSHKPKGGGGGGGGGGGGGGGGGGGGG------GGAPAGLGGLFA--GGIPKLRSAGSAAS-DSAPS-- RGPVFPPGGR---SGGPTPFGGGGGS-----------TGPPKLPGAPAGGRGNVPDLPKGRPSFSSRQDT---PGG-PPP VPNTPRPSQ-AFQPRGGLPPPALPGGPRPPPSSGPPPPGLPPGRQG-LPP------------------------------ -----------------------------------PGGSPAGPRPGFSAPLPPP-PNSSRPSLPPTPPGGRP-------- -PLPDDRP--PPPPLGGHRPSMPRD-VPPPPP-----PSGNSK----------PP--PPSRP--------PLPSVPRP-E GA-RPPYRLADR-APLLSRPPR--LA-------------------------------VTTT---TPPACP--------RG TCRSAVHISSPKGPLPPLPPSGRGVGGGSLRSLPPPSPIGRPGP----EPPRGGTGSRPPLPPDRPGV------------ -GGAPPPPP----------------------------------------------------------AHMGNGFQNSHHN ---QEWEYRFTFHPVSDLPPPEPYVHFQKT----------YPSKLGKTDGR--AGAGKNERGAPPLPPLPR--------- --------- >Human_WIPF2 MPIPPPPPPPPG--------------------PPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRS APILEKPKGSSGGY---------------------------GSGGAALQPKGGLFQ--GGVLKLRPVGAKDGSENLAG-- KPALQIPSSR---AAAPRPPVSAAS---------------GRPQDDTDSSRASLPELPRMQR----------------PS LPDLSRP--------N----TTSSTGMKHSSSAPPPPPPG---RRANAPP------------------------------ --------------------------------------TPLPMHSS------KAPAYNREKPLPPTP--GQR---LHPGR EGPPAPPPVKPPPSPVNIRTGPSG--QSLAPP--------------------PPPYRQPPG-------VPNGPSSPTNES -----APELPQRHNSLHRKTPG-----------------------------------PVRGLAPPPPTSASPSLLSN-RP PPPARD-PPSRGAAPPPPPP-VIRNGARDAPPPPPP--YRMHGS----EPPSRGK---PPPPPSRTPA------------ -GPPPPPPPP---------------------------------------------------------LRNGHRDSITTVR SFLDDFESKYSFHPVEDFPAPEEYKHFQRI----------YPSK----TNR------AAR-GAPPLPPILR--------- --------- >Mouse_WIPF2 MPIPPPPPPPPG--------------------PPPPPTFNQANTEQPKLSRDEQRNRGALLQDICKGTKLKKVTNVNDRS APVIEKPRGSSGGY---------------------------GPGAAALQPKGGLFQ--GGVPKLRPVGAKDASEAPAG-- KPALQVPSSR---AAAPRPPGSAAS---------------GRPHDDTDSNRASLPELPRMQR----------------PS LPDLSRP--------N----TASGTGMKHSSSAPPPPPPG---RRANAPP------------------------------ --------------------------------------TPLPLHSN------KAQAYNREKPLPPTP--GQR---LHPGR EGHPAPPPVKPPPSPVNIRTGPSG--QSLAPP--------------------PPPYRQPPG-------VPNGPSSPTNES -----APELPQRHNSLHRKTPG-----------------------------------PVRGLAPPPPTSATPSLLSN-RP PPPARE-PPSRGAAPPPPPP-MIRNGARDAPPPPPP--YRMHGS----EPPSRGK---PPPPPSRTPA------------ -GPPPPPPPP---------------------------------------------------------LRNGHRDSITTVR SFLDDFESKYSFHPVEDFPAPEEYKHLQRV----------YPSK----TNR------AAR-GAPPLPPILR--------- --------- >Rat_WIPF2 MPIPPPPPPPPG--------------------PPPPPTFSQANTEQPKLSRDEQRNRGALLQDICKGTKLKKVTNINDRS APVIEKPKGSGGGY---------------------------GPGAAALQPKGGLFQ--GGVPKLRPVGAKDAPETPAG-- KPALQVPSSR---AAAPRPPVSAAS---------------GRPHDDSDSSRASLPELPRMQR----------------PS LPDLSRP--------N----TTSGTGMKHSSSAPPPPPPG---RRANAPP------------------------------ --------------------------------------TPLPLHSN------KAQAYNREKPLPPTP--GQR---VHPGR EGHPAPPPVKPPPSPVNVRTGPSG--QSLAPP--------------------PPPYRQPPG-------VPNGPSSPTNES -----APELPQRHNSLHRKTPG-----------------------------------PVRGLAPPPPTSATPSLLSN-RP PPPARD-PPSRGAAPPPPPP-MIRNGARDAPPPPPP--YRMHGS----EPPSRGK---PPPPPSRTPA------------ -GPPPPPPPP---------------------------------------------------------LRNGHRDSITTVR SFLDDFESKYSFHPVEDFPAPEEYRHLQRV----------YPSK----TNR------AAR-GAPPLPPILR--------- --------- >Opossum_WIPF2 MPIPPPPPPPPG--------------------PPPPPTFNQANIEPPKLSRDEQRGRGALLQDICKGTRLKKVTHINDRS APVLEKPKGGSGGY---------------------------GSGINALQSKGGLFQ--GGVPKLRPVGTKDISENLAG-- KTVLQVSGSR---ATAPRPPVSTGS---------------NRPQDDSDSSRASPPELPRMQR----------------PS LPDLSRP--------N----STSSTGMKHSSSAPPPPPPG---RRANAPP------------------------------ --------------------------------------APLPMHSN------KAPTYNREKPLPPTP--GQR---PPPGR EGPPAPPPIKPPPSPVNIRTGPSGHNQSLAPP--------------------PPPYRQPPG-------VPNGPSSPTNES -----APELPQRHNSLHRKTPG-----------------------------------LVRGLAPPPPTSASPSLQSS-RP PPPARE-PPSRGAAPPPPPP-LIRNGARDAPPPPPP--YRLHGST---EPLNRGK---PPPPPSRTPA------------ -GPPPPPPPP---------------------------------------------------------LRNGHRDSIATVR SFLDDFESKYSFHPVEDFPAPEEYKHFQRI----------YPSK----TNR------ATR-GAPPLPPIIR--------- --------- >Chicken_WIPF2 MPIPPPPPPPPG--------------------PPPPPTFSQANTEPPKLSREEQRGRGALLQDICKGTKLKKVTQINDRS APILEKPKGGSGER---------------------------GAAGQAAPSRGRAVP--CCAWWLTPLS---LPADSSG-- KQTLQVPGSR---AAAPRPPVPASN---------------SRPQDDSDNSRASPPELPRTQR----------------PS LPDLSRP--------G----TAGGTGMKHSSSAPPPPPPG---RRATAPP------------------------------ --------------------------------------APPPAHGP------KVSSYNREKPLPPTP--GQR---APAGR DGPPAPPPVKPPPSPVSIRTGSGAQSQSLAPP--------------------PPPYRQPPS-------VPNGPSSPITES -----APELPQRHNSLHRKTPG-----------------------------------PLRGLAPPPPASASPSLQSS-RP PPPARD-PPSRGAAPPPPPPPALDPALQARAGPGAG--GALLGMDGGGGRAWGGR---VGSEQRRAAAGLWWLWWLWWLR DGPSRALCPA---------------------------------------------------------AASGDFTQELLGV GLCPRVGCGGGACSAVVPPGHRKERRLRAVGCLQGGPRRGAPGA----ARR------FALHGLLAPGSTRSGGGSH---- --------- >Anolelizard_WIPF2 -------------------------------------------------------------------------------- ------------------------------------------------------------------------SDSPSG-- KQSLQVPGTR---SVAPRPAVSSSS---------------SRHQDDADNNRASPPELPRTQR----------------PS LPDLSRP--------N----SASSAGMKHSSSAPPPPPPG---RRANAPP------------------------------ --------------------------------------APPSMHNS------KVPSYNREKPLPPTP--GQR---LPGNR EGPPAPPPIKPPPSPVNLRTGPSSQGQSLAPP--------------------PPPYRQPPG-------VPNGPASPTNES -----APELPQRHNSLHRKTPG-----------------------------------PARGMAPPPPPSASPSLQSS-RP PPPARD-PPSRGAAPPPPPPPMIRNGGRDAPPPPPP--YRMHGSS---DPTSRGK---PPPPPTRTPV------------ -GPPPPPPP----------------------------------------------------------MRNGHRDSISTVR SFLDDFESKYSFHPVEDFPAPEEFRHFQRI----------YPSK----TNR------ATR-GAPPLPPIPR--------- --------- >Zebrafish_WIPF2 MPIPPPPPPPAG--------------------PPPPPTLSQANTTPPKLSRDEAKGRGALLSDICKGARLKKTTGVNDRS APLIEKPKGGGGGVSSSG-----------------------GGSSAPVQPVGGLFQ--GGVPKLRPVG-----DGSAG-- RSALHPHGTR---SAAPRPPGS-------------------QEDPDSPSQQVSPPESSRPQR----------------PS LPDLSRS-----PAGG----NSPSTGMKHSSSAPPPPPPMS--RRGNAP------------------------------- ---------------------------------------PAPLQKA------NAPLYNREKPLPPTP--EQRGPSPAPVR ENAP-PPPVKPPPSPASSRSSSSS-SSSLAPP--------------------PPPYRQQSG-------LSNGPSSPVNEA -----APELPQRHNSLSKKPSAAGHT-------------------------------PTRGHAPPPPPSPTP--QAG-RP PPPARE-PPGRGAAPPVPGQ-PSRNGRDAPPPPPPP--YRTHGTSS--DAPSRGK---PPPPPSRTPA------------ -GPPPPPPP----------------------------------------------------------IRNGH-TSIS--R SFVDDFESKYSFHPLDDFPPPEEYRHFTKI----------YPSK----ANR------AVMRGAPPLPPVGR--------- --------- >Fugu_WIPF2 MPIPPPPPPPPG--------------------PPPPPTFNVANTSPPKLSSSETKGRGALLSDICKGAKLKKVGVVNDRS APVLEKPGGGGSGGGGGSG----------GGGGSGGGGGGGGFGGGGPMGMGGLFQ--GGVPKLRPVGDGSAGGSVG--- RSALRPPGSR---ALAPRPPTGRSN---------------SPSPSE----RPIPS-DQRSHR----------------PS LPDISRPPSSS--NSS----SSIGSGMKHSTSAPPPPPPFNRGGRPNAPP------------------------------ --------------------------------------TPKT---------SSSSSHSRDKPLPPTP--NRG-------- --PTPPSSLKPPSS--SSRPPTGG--SSAPPP--------------------PPPYRPHTSGG-----ISNGPSHTDAGG -----APELPQRHNSLHKKQPSGNSS-------------------------------QGRSHAPPPPPSPSLSSQQAIRP PPPARD-PPGRR-AAPQVPTPGSRNGGRDAPPPPPP--YRVHSSTTSESHSRGGK---PPPPPSSSSIS----SSSSSRT PAGPPPPPPP---------------------------------------------------------MRNGH-SSISSSR SNIDDFESKFNFHPVEDLPPPEDYRHFNKV----------YPSK----NNK------AMMRGAPPAPPVGR--------- --------- >Medaka_WIPF2 ----------------------------------------QANNNPPKLNQGGAKGRGALLSDIHKGAKLKKV-VVNDRS APIIER--GGGSSGGGFG--------------------------GGGPMGMGGLFQ--GGVPKLRPVGGKDHGPVVGSLG RSALKPPGSR---PAAPRPPTGRSS---------------SPTPPN----RPSSSEPQRSHR----------------PS LPDISHSHNSS-----------SSGGMKHSTSAPPPPPPFNRGNRGNAPQ------------------------------ --------------------------------------APAS----------------REKPLPPTP--QRA-------- --PAPSSTARPPSS--SSRPQPSG--SHAPPP--------------------PPPYRPHLSGG-----VSNGPSDVDGGG -----APELPRRHNSLRKKHSSG-----------------------------------GRSQAPPPPPSPS--SQQGSRP PPPARE-PPGRR-AVPPAPPPSSRNGGRDAPPPPPP--YRGHSSGGSEPQIRVGK---PPPPVSSSAP-------PSTRT PAGPPPPPPP---------------------------------------------------------IRNGH-SSSSSSR PNTDEFEAKFVFHPIEELPPPDDYKPFSKV----------YPSK----SNK------AMLRGAPPAPPVMR--------- --------- >Stickleback_WIPF2 LPLLLPPPSPSF--------------------SLVPP---QANTTPPKLGSSETKGRGALLSDICKGTRLKKVGVVNDRS GPIIES----GFS-------------------------------GGAPMGMGGLFQ--GGVPKLRSVT----GPELH--- LSLLHPDGLVGG-SVGSRPPAG-SS---------------TPSPAN----KPSPPEHQRSHR----------------PS LPDISRPPNNN----G----SSTGGGMKHSTSAPPPPPPFNRGGRSNAPP------------------------------ --------------------------------------APPTPNMKPHAPPSSSSSHSREKPLPPTP--HRG-------- --HTPPGPVKAPPS--STRPPTGG--SSAPPP--------------------PPPYRPHTSGS-----VANGPSQVDGGG --GGGAPQLPQRHNSLHKKHTSGGGT-------------------------------QGRSHAPPPPPSPSPSSQQASRP PPPARE-PPGRKSAAPQVPPSVSRNGGRDAPPPPPPPPYRVHSSVASEAHSRVGK---PPPPPSSSS------SSLSSRT PAVPPPPPPP---------------------------------------------------------IRNGH-SSITSMK SSVDDFESKFNFHPLEDLPPPEEYRHFSKV----------YPSK----TNKA-----AMMRGAPPAPPVGR--------- --------- >Tetraodon_WIPF2 MPIPPPPPPPPG--------------------PPPPPTFNVANTTPPKLSSSETKGRGALLSDICKGTKLKKVGVVNDRS APVLEMIKSGGWSKRQG---------------------------GGGPMGMGGLFQ--GGVPKLRPVG----GGSVG--- RSALRPPGSR---AAAPRPPTGRSN---------------SPSPSE----RPAPS-DQRAHR----------------PS LPDISRPPSSSG-SSS----SSIGSGMKHSTSAPPPPPPFNRGGRGNAPP------------------------------ --------------------------------------TPKA---------SSSSSHSREKPLPPTP--NRG-------- --PTPPSSVKPPSS--SSRPPTGG--SSAPPP--------------------PPPYRPHTAGG-----LSNGPSHTDAGG -----APELPQRHNSLHKKQPSGNSS-------------------------------QGRSHAPPPPPSPSPSSQQGSRP PPPARD-PPGRR-AAPQVPTQGSRNGGRDAPPPPPP--YRIHSSATSDSHSRGGK---PPPP----------------RT PAGPPPPPPP---------------------------------------------------------MRNGH-SSVPSPK SNIDDFESKFNFHPVEDLPPPEDYRHFAKV----------YPSK----SNK------AMMRGAPPAPPVGR--------- --------- >Human_WIPF3 MPVPPPPPPPLPPPPPP-----------LGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRS APQIESSKG-----TNKEG----------------GGS-ANTRGASTPPTLGDLFA--GGFPVLRPAGQRDVAGGKTG-- ------QGPG---SRAPSPRLP------------------NKTISGPLIPPASPRLGNTSEAH--------------GAA RTAPPRPNV-----------PAPPPPT-----PPPPPPPLPPPLPSSSPIK----------------------------- -----------------------------------TPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPP------------- --PPPTPPPLPPASVLSDKAVKPQLAPLHLPP--------------------IPPP--LPLLP-----PCGYPGLKAE-- -PASPAQDAQEPP---APPPP-----------------------------LPPYASCSPRASLPAPP--LPGVNSS---- SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGR--PGAGGGKLNPPPAPPARSPT------------ -TELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPGPWLQAEAVG QSSDDIKGRNSQVTQASCL------------------------------------------------------------- --------- >Mouse_WIPF3 MPVPPPPPPPPPPPPPPPPPLGAPPPPPLGAPPPPPPPGPPVSTDTPSLRKPDLKGRSALLADIQQGTRLRKVTQINDRS APQIEGSKG-----TSKEG----------------GAAGSNARGGNTPPALGDLFA--GGFPVLRPAGQRDVSGGKSG-- ------QGPG---SRAPSPRLP------------------IKAISGPLPAPASPRLGNASETH--------------SSA RPVPPRPSV-----------PAPPPPT--------PPPPPPPPLPPASPIK----------------------------- -----------------------------------AQLVSPPAPPTKVNPSVVPPPLPCAPPLPPPP------------- --P--TPPPLPPASALSDKAVRPQLAPLHLPP--------------------IPPP--LPLLP-----PCGYPGLHSE-- -PNSPAQEVREPP---APPPPPPPPPPPP---------------------LPTYASCSSRTAVAPPP--LPGANNSG--- SETPPPLPPKSPSFQT------QKALPTPPGAPGPQAILQKKRRG---PGTSGGKLNPPPAPPARSPT------------ -TELSSK---------SQQPGGQLRNGGQHAIDDFESKFTFHSMEDFPPPDEYKPCQKIYPSKVPRSRTPGSWLQAEAAG QSSDDIKSRNSQLSLKALR------------------------------------------------------------- --------- >Rat_WIPF3 MPVPPPPPPPLPPPPPP-----------LGAPPPPPPPGPPISTDAPSLRKSDLKGRSALLADIQQGTRLRKVTQINDRS APQIESSKG-----TSKEG----------------GAAGSNARGGSTPPALGDLFA--GGFPVLRPAGQRDVAGGKTG-- ------QGPG---SRAPSPRLP------------------TKAISGPLPAPASPRLGNASDTH--------------SSA RPVPPRPSV-----------PAPPPPTTPPPPPPPPPPPPPPPLPPASPIK----------------------------- -----------------------------------APSVSPPVPPTKGNPSAVPAPIPCVPPLPPPP------------- --P--TPPPLPPASALSEKAVRPQLAPLHLPP--------------------IPPP--LPLLP-----PYGYPALHSE-- -PSSPAQDVREPP---APPPPPPPPPPPPPP------------------PLPTYASCSPRAAVAPPPPPLPGSSNSG--- SETPPPLPPKSPSFQT------QKALPTPPGAPGPQIILQKKRRG---PGAGGGKLNPPPAPPARSPT------------ -TELSSK---------TQQPGGQLRNGGQHVIG----------------------------------RTPGSWLQAEAAG QSSDDIKTRNSQLSLKALR------------------------------------------------------------- --------- >Microbat_WIPF3 MPIPPPPPPPPG--------------------PPPPPTFNQGNTEQIKLSRDEQRGRGNLLQDICKGTKLKKVT?????? ??????PKGSGGGY---------------------------GSGAGALQPKGGLFQ--GGVPKLRHVGAKDVSENLAG-- KPALQVPSSR---AAAPRPPGSTAS---------------GRPQDDTDSGRASLPELPRMQR----------------PS LPDLSRP--------I----TTSSPGMKHSSSAPPPPPPG---RRAAPP------------------------------- ---------------------------------------ALPMHS--------KAAYNRE-PLPPTP--GQR---LHPGR DGPPAP????????????????SG--QSLAPP--------------------PPPYREVPG-------VPNGPSSPTNES -----APELPQRHNSLHRKTPG-----------------------------------PVRGLAPPPPTSVSPSLQSN-RP PPPARD-PPSRGAAPPPPPP-MIRNGARDAPPPPPP--YR-HGS----EPLSRGK---PPPPPSRTPA------------ -GPPPPPPPP---------------------------------------------------------LRNGHRDSITTVR SFLDDFESKYSFHPVEDFPAPEEYKHFQRV----------YPSK----TNR------AAR-GAPPLPPILR--------- --------- >Opossum_WIPF3 MPVPPPPPPPLPPPPPP-----------TGAPPPPPPLAPPLSTEAPRPKKDAAQGRSALLADIQQGTRLRKVTQINDRS APQIETSKG-----ANKEG----------------GGAAGNSKGG-NPQALGGLFA--GGFPVLRPAGQRDGSGKKSG-- ------KGGG---SRAPSPRLP------------------TKIISSPVNPPASPRLGNAPEAS--------------AIS RPVPPRPNM-----------PAPPPPTT----PPPPPPPLPPSTSLPAMVK----------------------------- -----------------------------------PPLVSPPPLMTKTSTQIMVPPPP--PPTPPPP------------- --P----PPLQ-----GEKAGKPLVGPLNLPP--------------------VPPP--LPLLP-----PCGFPGQVSDAA SPASPQPELREPP---PPPPPPPPP-------------------------LPLYSSPTPRSSLSPAP--LPGSNNN---- ---GDPLPLKSPKASL-------QSMPLPPIPPASQSTILVQKKR---PGRGAG--------PTR--------------- ----------------------------------------------------------------------GSWLPTDATG RGNEDIKGRNSQRLLLEIFQG-FIHSFLMT----------APGV------------------------------------ --------- >Anolelizard_WIPF3 MPVPPPPPPPPLPPSLS------------GGPPPPPPLPPSANSEPPKARREDSKSRSALLHEIQRGTRLRKVTQTNDRS APQIESERR-----TSRDG----------------GNS--TSGRSDVPQALGNLFA--EGFPVLKPVGQRDLTGGKTG-- ------KPCT---LRMP-PRSPDSQN-----------N-NEKANGNFHVTPESPRPTEQPETP--------------KAQ PPTPTRPSI-----------PAP-----------PPPPPLPPSSSS----K----------------------------- -----------------------------------PSLVFPPPPP-------LPPPLAESPDKLTSP------------- --STAAAVSLP----HNEKLPKAQTSPLNMPP--------------------LPPPPPLPLTS-----PCGTSGRTNE-- -GSSSQTDVRTNPPLMSPPPPPPPP------------------------HMSTFS--SPRSSLSSPT--SPSSNNALSGS SDIAPPLPPKSLFVQS-----QMEKANIQSLPLSPTVVVQKRRQGR--GGGKNWKLNPPPVPPARSPT------------ -TELSSK------------------------------------------------------------SHSQSYRLNNVFL HTVDDFESKFTFHSVEEFPPPDEFKPCLKI----------YPS------------------------------------- --------- >Stickleback_WIPF3 CPACPPPTQRPTLLESLR-----------LLDTAVRP----------SLSKASQAQRNALLADIQKGARLKKVTQVNDRS APSVDTVKANTGDVPSSGA----------------ASQGSSGGPAPMGPSLGGLFA--AGFPTLRPTGQRDLAGKTT?-- ------PRVS---SSTAR-KAAS-----------------QGARTPSSGTPAAPPRLHGLPST--------------AAR TAP-FPLLS-----------PTAPPRPLRSSPAPPPRLPGTSGR---QAPP----------------------------- -----------------------------------LPSCPPPPPPYQVTKPTCSPSS----------------------- --PSTPPPPPPPPFQPPKAEAGDRKSGCFYPL--------------------PPSP------------------VHSE-- --PSRFSILRDSPLGPPPPPPAPPLP-------------------------ASFGPSCPSTLPPPPPKLAAVPSPAM--- RSLPPSYPCNAPTRRPP---AVPRSAGMSPHPWSDTPLTPVMSSP---MATGVGRLPPPPAPPARSPS------------ -TELSCRTP----------------------------------------------------PPPPPPPLLPLSLRNGHLH SLADNFESKFQFHPVEDFPPPDEFKPFPRI----------YPSKENRGSSMSQVRLNPPLPPTTT--------------- --------- >Tetraodon_WIPF3 LPVPEPGPAWKTTPPPLA-----------PAPPPPPPPTAVTRHSTFSLFFTFISHRNALLADIQKGAKLRKVTQVNDRS APVVESR-------TSSPA----------------ASQGSSGGLAPIGPSLGGLFA--GGFPTLKPIGQRDSAGKSSG-- ------AADT---RNVPEPPSKT-----------------VEVRNAINRQPSSTASAPASPSQ--------------SSR HPPPFPATC-----------PPPPPAVPPSALPPPPPPPLPQDRPVSKPPP----------------------------- -----------------------------------LPSCPPPLPPSQAAKPTWLPAQHSHHTAVSQP------------- --PTPPPPPPPPPYQTPSHVPGDRSSGCFYPP--------------------PPPH------------------IHTE-- --PARS--FRESALGTPPPPPPPPL------------------------------------LLPPPPKLAPVPSPSP--- ACAASLIPLQCSNQTTP---FCPQKCRNISIPY--TSLTPVYSLP---MVTGAGRLAPPPAPPARSPT------------ -TELSSRT---------------------------------------------------------------ASLRNGHLH SLDD-FESKFQFHPVEDLPPPDEFKPFPRI----------YPSKENRGT----------FP------------------- --------- >Hydra_WIPF1 --MPPPPPPPPP------------------SAPPPPKVNTDGGVKKTGGGGDAGAGRGMLLSSIQTGAKLKKT-VTNDRS SPQIGKVNNGPSGGNELSHGV--------------------KEAGSCGPPMSGMFA--GGMPKLRPAADKGKPGGGGGAA ILPPNKRSPPQN-NESNQPPNSYPSP-----------INPTSSSGNLAGQRLPTPQTNSKPPP---------------PP SRELSYDQQRV------GVASLQNDSVSLPISNKPPQLPSNQNRSGALPT------------------------------ -----------------------------------------------------QTNVRGPPPISVNP------------- ----------PPPPPNRSSGPPNSSRTAPPPP------------------------------------------------ ------PSRDSLNTRNLPPPPPNRMG----------------------------------------------------GN PSQNDSLRRVASSSSIGGIEINVSSSFSNQPPPPPVHRTSVTTAPPRQRSATTDDIQPPPPPPPRGSG------------ --------------------------------------------------------------------MRQSMVFPPPPS PLDSNYEARFQFS--NDFPDPDQFRNIQKT----------YPSKAAKNNEKKQNQFNIPNRSAPPPPPSGRNAPLPPPPP PPNRR---- >Caenorhabditiselegans_WIPF1 --MPPPPPPPP---------------------PPPPPPPPAASAPPPS-----SNARNALLGDIHKGLKLKKT-VTNDRS APSVGKVVGSSGSSSNGNS---------------GNGNGPAAKPPQMSGGLGGLFA--NGMPMKPSENKIRRATTSIG-- ------PPPTAS-SAPPVPPPAPVP----------------AVEGKKPSIVSSSSFSHHGATS----------------- -------------------------------SAPPPPPPPP--------------------------------------- -----------------------------------------------------PVSVPSSKPTPPPP------------- ------PPAQQKPSFQSDREQFRTMRPLRPAN-------------------------------------DVKPTMYRRSG ----SSEDIPQATSATRLARPLAPPP--------------------------------ARPAAPPPPVPTPSIAQMSSRF QSPAISRTLDDAPPPPPRIASKTSVAPTSSRAPLPPSSSFAPSIS---ASPAPAP---PPPPPQAASP------------ --------------------------------------------------------------------YPGMKSTATVSA NVPFHPLNRFHFLPLSQLPPPPKVSSGSIRA------------------------------------------------- --------- >Seaurchin_WIPF1 ---MPPPPPPPG--------------------PPPPPTFKQANTTPPNLNKNEQKNRGALLGDIHKGMKLKKTVTVDK-S GPLLECVK---------------------------------------------FLK--CLVLQRRPVNVTSVSQNKFG-- ------NGGK---PSGGGLPASRPL---------------PHPSGNS---RPLPSQPQNTHN----------------PV SARISNK--------------GSSNGHGAADRAPPPPPPSSNRPRPPSTS------------------------------ --------------------------------------FPPPPPSS-------LPSSKPSNNFPPPP--PTS-------- -SIPSRNSRAPPPP---KRDPPSK--GSTPPP--------------------PPPQGRIDN-K-----LSNGPS---TGP -----PPPPPSRQPPGGRPPPPPRDT-------------------------------PRPGTAPPPP----PPSRSQGRP PSTVS---SSSSRAPPPPPN---RTSTGHSAPPPPS---RDKGPRP--PSIVGGP---PPPPPSRGTP------------ -RSPPARNPP---------------------------------------------------------ARDSG------IM NGTDDFESRFRFNSSSRFPTPPPMKKLQKT----------YPSKQ---PNRQ-----STKRGQPPAPPRQ---------- --------- >Anophelesgambiae_WIPF1 ----MPPPPPPG--------------------PPPPPGPPPPPALKLGGGAPSADGRNALLLSIQKGAKLKKTVTVDKSA PAIQGKVTSDGGATRANNRAP------GRPTGDDGAPAAAGPTIGGGQPKLGGLFEGLSSMPKLKPVGSRTGAGTGKEAG WELPGVCRICLIFYTETHVPQRLTY--------------IAHVGVTLLPQETHLRQHLGISRTKR------------PPR TPRKPINNG----------RLGNGGANLRLNRGPPPQPPTSIQRVRQKGSGLHRTVQCN--------------------- ---------------------------------DMTFFPLFPAIRRQFGVKDRTGTALLHSQAPATPN-----------H LKLAGSKPSSATNGPMSAIHSSAAAAASTSPTINATGGSAPIPNRSALFGGTTTTTVPTTANSS---IAMGNGSVPSVAA VPVAPKPVPNYGKPNLAPKPPGMQLG-----------------------------GTAADGGSGTRPTVSRHQSMRSPRS PPVSQTAPAFPANHFGTMRGPPSSAAMFQSSESIVRPVREVTGRPS-APPPKPPTMKPPPPPPVRSVSNTNLTHLPPSLS LAPSSQDNTGG-------------------------------------------------TSSPATEPTTFGSVNNVSTL TLADELRAKVSNVNLSVAGSSANSISTGNLSVLGGGSTLTKGGSLKTTAAPPLPPHRTSPAPPPPVPASTLVSNSGEAPV PPQRISSIR >Cionasavignyi_WIPF1 ----MLG------------------------IPPYYKQFYSQFRKIHSSESIDVYSFGHLLYEMVYGRQLNKS-TIDMLP VSSPAEIRS-------------------------------------VLESILSVEACKNGLPTLEGLLIHPLFADETVT- -------------TVGIKPQLKIPS----------------KLKETFRQYKEAMERKLKEEQK----------------- -------------------------------------------------------------------------------- -------------------------------------------------------VISQTRRLSKVK------------- -------AHHSSDSERRRRKLEAR-------------------------------------------------------- -------KKSQMKLDIVEESPD---------------------------------------------------------- ---------KSGDGMTPTTPASNTSSATTPVTGVPP------------APPMAPSLEPPPAPPMLNGK------------ -----------------------------------------------------------------------------SPT EAPAPAGRGALLGSIQDFSKSKLRKSVTVD------------------------------KSNPKI-------------- --------- >jellyfish_WIPF3 --MPPPPPPP---------------------GPPPPPSAPSGPVKPP----PSSKNRGALLSDIHKGARLKKT-VTNDRS APVVANEKKSSSGGN-LSSSS--------------------SSTGGGGG-----FS--GGG--------GGSMGGGG--- ------------------------------------------LGGLFAG------------------------------- -----------------GMPKLR---------------PAGERKAAGAG------------------------------- ---------------------------------------------------------RRPPSGKINP------------- ----------PPPPP----------------------------------------------------------------- ------PAMD---------------------------------------------------------------------K PS------------------------FTNGP--------------------VSNNIMDS--------------------- -------------------------------------------------------------------------------- --KNSFECRFNFRTLNELPPPEPYQDTPKT----------YPSKNQQKANRGNPRPASSSRGAPPPVPPSR----GPPPP PPRQ----- >Drosophila_WIPF3 MAIPPPPGPP----------------------PPPGPPPPPAMGGLKLGGAGGADARSALLSSIQKGTKLKKTTTVDKSG PALSGKVCGGDGGAGIGAKR---TLNNNTSTSNHNNSSSSSNGLGNGTPKLGGLFEGLSQMPKLKPVNGIRATPSAGSAA TTTSKSTTNSSAQQRSNSPPAATSASNASNGPMDFNTELTKHLTLKRQKQQQQQQPQPPTNNTHINATEANLRTNRGPPP QPPKSANSNDSILERMNIPRTAPTPPFGNSSSVKAASPTLSDSGSNSSGSGGGSGSVKSKAANLNISLGNSFVNSSKSTV SASTASLNSSLTSSTGSVRNLAPNKSTLFGGSSGSSSGSSSGGGYASVHKSSPPSTADSTPSVTPTPPPLQLP----MKP AISFGKPNFAPKPPGLNQLAMANGQQRPAVTRHHSMKSPRSPPAAGIVNGLVFPTQQHLGTLRGPLQFHGSESSSPNTSA GSMRCAPNPPKSRPSVKPPPPPTPARSFSNTNLNNIGGSTMFSAVNTALIQSSAISSQAPSPPITQPPSSSSSSNSVAAL RDQFRGGAGMSNGAPSPPLPPTPAPSSNPSSASASPKSLLRDNVKP--IILNGGPLNPPAPPPHRSCPPPPPPQRQSSNG GSGSGSAPVP--------------------------------------------------------PQRHSSIRPNAPST PPTHMANASHQFGSSSGLSSGSGAGAAASVGRLVNDLETKFGKRFHNVTEFPKPPPFLNIQKVYPSRTFKATNGM----- ---------